أ.د. اشرف الهاورني - السيرة الذاتية

CURRICULUM  VITAE

 

Professor Dr. ASHRAF  A. EL-HAROUNI

M.B.B.CH,  M.Sc. , Ph.D .

Personal  Data:

Name:       Dr. Ashraf Abd El-Rahman Mostafa El-Harouni.

Date of Birth:12 / 11 / 1959        Place of Birth: Cairo, Egypt     

Age: 49 years.  

Sex: Male          Nationality: Egyptian     Status: Married.

Home Address:           2 Mostafa Hassanin Street , Manial, Cairo, Egypt.

Employment: Professor of Clinical Genetics, Head of Clinical Genetics  Department, National Research Center, Cairo, Egypt .

Employer’s Address:  El-Tahrir Street , Dokki, Cairo, Egypt.

Languages: Arabic , English.

 

Qualifications:

 

                         · Bachelor of Medicine(M.B.B.CH)

Faculty of Medicine, Cairo University, 1982 .

  Grade : Very Good with Honor .

                 · Master of Pediatrics ) M.Sc)

Faculty of Medicine , Cairo University, 1986.

 Grade : Very Good .

                    Thesis Title: Pathologic Changes and Genetic Patterns of Certain Neuromuscular Disorders.

 

                    · Ph.D. of Human Genetics :

Institute of Medical Research, Alexandria University, 1992

Thesis Title: Clinical, Genetic, and Ultrastructure Studies of Selected Neuromuscular Disorders.

 

Employment History:

 

                    · House officer in Cairo University Hospitals - 1/3/1983 -28/2/1984.

                    · Specialist in Human Genetics Dept.,  National Research Center, 1/3/1984  - 14/9/1987 .

                    · Pediatrics Visiting Resident, Cairo Univ. Children Hospital & The Pediatric Neurology Unit, 1985 - 1986.

                    · Assistant Researcher, Human Genetics Dept., National Research Center, 15/9/1987 - 20/1/1993.

                    · Researcher of Human Genetics, Human Genetics Dept., National Research Center, 21/1/1993 - 21/1/1998.

              · Associate Professor of Clinical Genetics, National Research Center, 21/1/1998 - 28/2/2003.

              · Professor of Clinical Genetics, National Research Center, Present.

              · Vice-President of The Division of Human Genetics & Genome Research, National Research Center, Cairo: 2003-2006.

                    · Head of the clinical Genetics Department, National Research Center, 2003-2006.

 

Scientific Activities: 

  • Membership of The Research Bioethics Committee, National Research Center, Cairo, Egypt.
  • Membership of The Egyptian Pediatric Genetics Society .
  • Membership of The Middle East Genetics Association of America (MEGA) .
  • Membership of The Egyptian Society of Child Neuro-Psychiatry (ESCNP).

 

ATTENDED TRAINING COURSES IN:

 

  • Course On Electron Microscopy, Faculty of Medicine, Ain Shams  University March1987 .
  • The Laboratory Diagnostic Methods of Cytogenetics, Human Genetics Dept., National Research Center, Cairo, Egypt, Nov., 1988 .
  • Course of Human Genetics : Clinical, Molecular and Cytogenetic Diagnosis of Genetic Disorders, Human Genetics Dept., National Research Center, Cairo, Egypt, Dec., 1992.

 

TEACHING STAFF IN TRAINING COURSES:

 

  • First Course in Neurogenetics (European School of Genetic Medicine), Rabat, Morocco, June 8th – 11th, 2005.
  • Course of Clinical Genetics and Cytogenetics, Human Genetics Dept., National Research Center, Cairo. Jan. - March, 2002.
  • Course of Clinical Genetics and Early Intervention of Mental Retardation, Human Genetics Dept., National Research Center, Cairo. Nov. 2001 .
  • Course of Clinical Genetics and Early Intervention of Mental Retardation, Human Genetics Dept., National Research Center, Cairo. Nov. 2000 .
  • Course of Early Intervention and Rehabilitation of Down’s Syndrome, Human Genetics Dept., National Research Center, Cairo. Nov. 1998.
  • Course of Clinical Genetics, Human Genetics Dept., National Research Center, Cairo, Egypt, April - May, 1997 .
  • Course of Human Genetics : Clinical, Molecular and Cytogenetic Diagnosis of Genetic Disorders, Human Genetics Dept., National Research Center, Cairo, Egypt, March, 1995.

 

  • Course of “Applications of The Transmission and Scanning Electron Microscopy in Studying Some Samples from Different Specialties”. The Electron Microscope Laboratory, Physics Dept., Faculty of Science, Cairo University, Dec., 1993.

 

Scientific Missions & Training Periods Abroad :

 

  • Scientific mission in The Department of Molecular Biology, Institute of Cell Biology, Counsel of National Research (CNR) of Italy - Rome  & The Institute of Neurology, Catholic University, Rome, Italy. Training on advanced techniques required to differentiate between the various forms of muscular dystrophies by studying muscle biopsies by immunohistochemistry and immunoblots for different muscle proteins. DNA analysis for dystrophin gene from patients with Duchenne & Becker muscular dystrophies. ( May & June, 1995 ).
  • Scientific mission in The Department of Molecular Biology, Institute of Cell Biology, Counsel of National Research (CNR) of Italy, Rome. For analysis of DNA samples from Egyptian families affected by progressive muscular dystrophy by multiplex PCR using primers specific for different exons of the dystrophin gene, and studying of segregation of dinucleotide (CA)n polymorphic markers for haplotype assignment and carrier detection in DMD/BMD families. ( Oct. & Nov., 1996 ).

 

Projects:

 

Principle  Investigator  of  the  Project  of:

 

  • New Horizons in the Diagnosis of (Duchenne/Becker) Muscular Dystrophies. Granted by The National Research Center, Cairo, Egypt,          2002 - 2005.

viCE-principle  investigator  of  the  project of:

 

  • Mutational Analysis of Patients and Carriers and Prenatal Diagnosis of Autosomal Recessive Spinal Muscular Atrophies. Granted by The National Research Center, Cairo, Egypt, 2002 - 2005.

 

 

Investigator In tHe Projects of:

 

  • Design of Kits for the Diagnosis of Phenylketonuria and Duchenne Muscular Dystrophy. Granted from The Egyptian Academy of Scientific Research and Technology, Cairo, Egypt, 1998 - 2003.

 

  • Genetic Diagnosis of the Patients Referred to the Clinics of Human Genetics Department, Studies of Consanguineous marriages, FICH, Prenatal Diagnosis, and Studies of Gingival Biopsies by Electron Microscopy. Granted by The National Research Center, Cairo, Egypt,   1998 - 2001.

  

  • Diagnosis and Prevention of Progressive Muscular Dystrophies in Egypt. In The Frame of Scientific and Technological Cooperation Protocol Between The Egyptian and The Italian Governments : The Egyptian Academy of Scientific Research and Technology, Cairo, Egypt & The Counsel of National Research (CNR) of Italy, Rome, Italy, 1994 - 1996.

 

  • Clinical, Biochemical and Genetic Studies of Congenital Malformations. Granted by The National Research Center, Cairo, Egypt, 1992 - 1995 .

 

  • Prevention of Genetic Diseases and Malformations in Newborn, Achievements of the Research in the Five Centers. Granted by The Egyptian Academy of Scientific Research and Technology, Cairo, Egypt,1991 - 1995.

 

  • Screening of Genetic Disorders and Birth Defects in Two Egyptian Villages in Giza Governerate. Granted by The National Research Center, Cairo, Egypt, 1989 - 1993.

 

Current   Research :

  • Diagnosis and management of different genetic disorders in the “Human Genetics Clinic”, National Research Center, Cairo.
  • Continuos Genetic Counseling in the "Human Genetics Clinic",National Research Center, Cairo.
  • Diagnosis, management and follow up of patients with different forms of neurological and neuromuscular disorders , in the clinic of "Inherited Neurological & Neuromuscular Disorders", Clinical Genetics Dept., National Research Center, Cairo.
  • Studying of muscle biopsies from patients with different forms of neuromuscular disorders by light & electron microscopy as well as immunohistochemistry techniques.
  • Interpretation of the results of DNA analysis from Duchenne/Becker muscular dystrophy patients & Spinal muscular atrophies patients.
  • Participation in the different projects of the Division of Human Genetics &Genome Research., NRC, Cairo, Egypt.
  • Participation in the activities of Research Bioethics Committee , NRC, Cairo (Teaching programs, Workshops, Meetings and Supervision of research  protocols presented by different departments in NRC).

 

Participation in Scientific Meetings :   

  • The VIIth International Congress of The Pan Arab-African Council of Ophthalmology, 22nd Congress of The Tunisian Ophthalmological Society, May, 22-25, 2003,  Tunis.
  • Chairperson of the Neurogenetics Session, 9th PNUNS (Pan Arab Union Of Neurological Science) Congress, Cairo & Sharm El-Shikh, 13-17 January 2003.
  • The Xth International Congress on Neuromuscular Diseases, Vancouver, British Columbia, Canada, July, 7 - 12, 2002.
  • The 3rd CNC Cairo International Neurology Conference, Cairo, Egypt, January, 8 - 10, 2002.
  • Meeting of Cooperative International Neuromuscular Research Group, Children's Research Institute, Children's International Medical Center, Washington DC, USA, February. 15-18, 2001.
  • The 3rd Annual Conference of Hereditary Blood Diseases, Fayoum, Egypt, April, 12 -13, 2001.
  • The 7th Annual Congress of the Department of Pediatrics, Ain Shams University, Cairo, Egypt, March, 1 - 2, 2001.
  • Conference of Egyptian Society of Neurology, Psychiatry and Neurosurgery. Assiut, Egypt, Oct. 4 - 6, 2000.
  • The 2ed International Conference of The Middle East Genetics Association of America, on Population &Molecular Genetics Update. Nov.30th-Dec.2ed, 1999.
  • International Congress on Molecular Genetics. Cairo, Egypt, Feb. 21-25,1998.
  • The 8th International Scientific Congress of The Egyptian Medical Society (Medicina ). Cairo, Egypt, 12 - 15 Dec., 1996 .
  • 3rd Asian-European Workshop on Inborn Errors of Metabolism. Egypt ;   Cairo: 17 - 19 Sept., 1995;  Luxor & Aswan: 20 -23 Sept., 1995 .
  • XXI International Congress of Pediatrics. Cairo, Egypt, 10 -15 Sept.,1995 .
  • The First International Conference of Human Genetics and Physical Anthropology. Cairo, Egypt, 9 - 12 Dec., 1989 .

 

 

Scientific Supervisor of Thesis:

  • M.D. Thesis On Neurology

           Neurology Dept., Faculty of Medicine, Cairo University .

  • M.D Thesis On Pediatrics

           Pediatrics Department, Faculty of Medicine, Cairo University.

  • M.Sc Thesis On Neurophysiology :

           Neurophysiology Department, Faculty of Medicine, Cairo University.

 

       Previous Collaboration With Johns Hopkins University:

       I'm belonging to a research group had experienced previous collaborations with

       Johns Hopkins University  (Professor Samia A.Temtamy and two of her

       coworkers: Dr. Ibtsam R. Hussein & Dr. Yahia Z. Gad) in the labs. of Professor

       Victor  McKusick, Professor Kazazian & Professor Claude J. Migeon   

        respectively.

 

Publications from  Ph.D Thesis  :

El-Harouni A.A., Aboul Ezz E. H. A., Fadaly G. A., Abdel Salam M., Hindawy A., Nassar A. M., Ismail S. R., 1994. Neuromuscular disorders in Egyptian children: A clinical, genetic and ultrastructure study. The New Egypt. J. Med. Vol. 10, No. 2 p.p. 532 - 537.

 

 

List of Publications :

 

1-Temtamy S. A., Abdel Salam M., Aboul Ezz E. H. A., Mahmoud A. N., El-Harouni A., Sabour Y. A., Helmy S. H., Hussein H. A., Mahmoud K.Z.: Genetics of primary infertility in Egyptian men. Egypt. J.  Androl. Reprod. Vol. 8, No. 1, 95 -116,1994. 

 

2-Temtamy S . A., Meguid N. A., Aboul Ezz E. H. A., Abdel Nasser W.,  El-Harouni A. A., Afifi H. H., Bassiouni R. I.: Genetic/ Epidemiologic studies of birth defects in Egyptians. The proceedings of the Symposium on “The Medical Genetics In The Setting Of Middle Eastern Populations”, College of Medicine and King Khaled University Hospital, King Saoud University, Reyadh, Saoudi Arabia      (26 - 28 October, 1993), p.p. 127 - 136, 1994.

 

3- El-Harouni A., Aboul-Ezz E.H.A., Temtamy S.A.: Mitochondrial abnormalities in muscle and gingival biopsies from patients with different forms of mitocondrial myopathies. The Egypt. J. Ped.Vol.13, No.1-2, 1-10, 1996.

 

4- El-Harouni A.A., Aboul-Ezz E.H.A., Meguid N.A., Temtamy S.A.: Central nervous system involvement in progressive congenital muscular dystrophy  ( Fukuyama type?) in two Egyptian families. The Egypt. J. Ped.Vol.13,  No.1-2, 83-92, 1996.

 

5- El-Harouni A.A. , Mahmoud A.M. ,  Kamel A.K. , Shehab  M.: Prader - Willi syndrome in Egyptian  children : Clinical and cytogenetics studies. The Egypt. J. Ped. Vol.13, No.3-4, 133-144, 1996.

 

6-Meguid N.A., El-Harouni A.A., Afifi H.H., Temtamy S.A.: An autosomal recessive  pterygium syndrome with severe muscular atrophy : Escobar type. J. Arab Child,Vol.8, No.1, March, 81-88, 1997.

 

7-Meguid  N.A.,   El-Harouni A. A., Temtamy S. A.: “Genetic, therapeutic, and immunologic studies of Schwartz Jampel syndrome in Egypt”. J. Arab Child Vol. 8, No. 3, Sept., 355 - 362, 1997.

 

8-Temtamy SA., Aboul-Ezz EHA., Meguid NA., Fatten EM .,               El-Harouni AA.: Newborn screening for some inborn errors of metabolism in Egyptians. The proceeding of the Symposium on “ The Medical Genetics In The Setting Of Middle Eastern Populations”, College of Medicine and King Khaled University Hospital, King Saud University, Reyadh, Saoudi Arabia (26 –28 October, 1993), pp. 283, 1994.

                                       

9-Meguid NA.,  Mahmoud AM., Kamel AK.,  El-Harouni AA., El-Rouby M., Helmy N.: The Triple X females : Wide phenotypic spectrum. The New Egyptian J. of   Medicine. Vol : 18  No: 6, June,1998.

 

10-Hussein IR., Temtamy SA ., El-Harouni AA., Essawi ML., Al-Awady MK., Selim LA., Feliccetti L.: Molecular and genetic studies in DMD and BMD in Egyptian patients. Egyp. J. Ped. 16; 3:  245-264, 1999.

 

11- Effat LK.,  El-Harouni AA.,  Amr KS.,  El-Minisi TI.,  Meguid AN.,  Al-Awady  MK.: Screening of dystrophin gene deletions in Egyptian patients with DMD/ BMD muscular dystrophies. Disease Markers 16: 125 -129,2000. (Presentation in the Xth International Congress on Neuromuscular Diseases, Vancouver, British Colombia,Cnada, July, 7-12, 2002)

 

12- El-Harouni AA.,  Al-Abyad RA.,  Galal AH.,  Effat LK.,  Meguid NA.: Ocular changes of Duchenne muscular dystrophy  in Egyptians.  Med. J. Cairo Univ., Vol., 68, No. 2 : 57 – 63, 2000.(Presentation in the VII International Congress of The Pan Arab-African Council of Ophthalmology, 22nd  Congress of The Tunisian Ophthalmological Socity, May, 22-25, 2003, Tunis).

 

13-Laila A. Hosny, Nagwa A. Meguid, Mouchira E. Zaki, Olweya M.AbdelBaky ,Ashraf A. El-Harouni, Mohamed A. Awad Alla, Adel M. Ashour: Genetic and anthropomertric studies of mental retardation. The Egyptian           Journal of  Pediatrics, Vol. 18 No 155-169, 2001.

 

          14- Ashraf A. El-Harouni, Mona L. Essawi, Amina Hindawy:Neuronal apoptosis inhibitory protein (NAIP) gene deletions in Egyptian children with           spinal muscular atrophies. Med. J. Cairo Univ. Vol. 69, No. 4: 733-738, 2001. 

(Presentation in the Xth International Congress on Neuromuscular Diseases, Vancouver, British Colombia,Cnada, July, 7-12, 2002)

 

15-Ashraf A. El-Harouni, Maha S. Zaki, Ekram M. Fateen, Nagwa A. Meguid: GM2 gangliosidosis: Clinical, genetic and biochemical studies among Egyptian patients. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, Vol. 39 (1): 87-96, 2002.

 

16-Ashraf A. El-Harouni, Ann A. Abdel-Kader, Manal Fahmy, Ekram M. Fateen: Genetic background of juvenile myoclonic epilepsy among Egyptians. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, Vol. 39 (2): 311-320, 2002.

 

17-Ashraf A. El-Harouni, Shahira R. Noir, Amany H. Galal: Ocular manifestations of chromosomal abnormalities.  J A C., Vol. 13, No. 5: 585-597, 2002. 

 

18- Ashraf A. El-Harouni, Maged abdel-Naseer, Khalda S. Amr: Benign X-linked Becker muscular dystrophy among Egyptian patients. Med. J. Cairo Univ. Vol. 71, No. 3(suppl.): 121-128, 2003. 

 

19- Samira Ismail, Maha S. Zaki, Ashraf A. El-Harouni. Callosal dysgenesis: Clinical and genetic studies in 55 Egyptian patients. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, Vol.40(1): 1-10, 2003.

 

20- Ashraf A. El-Harouni, Ehab R. Abdel-Raaouf, Ekram M. Fateen, Amany H. Galal, Nagwa A.Meguid. Neuroimaging studies in Egyptian patients with mucopolysaccharidoses . J A C., Vol.14, No.2:133-143,2003.

 

21- El-Harouni AA, Amr KS,  Effat LK, Eassawi ML, Ismail S, Gad YZ,.   El-Awady MK : The milder phenotype of the dystrophin gene double deletions. Acta Neurologica Scandinivica., 107:400-404,2003.

       

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